POSTER SYMPOSIUM: ONCOGENES AND GROWTH FACTORS

Growth factors, oncogenes and the autocrine hypothesis.

Many aspects must be studied when considering theories of oncogenesis. Growth factors, the polypeptide hormones that are necessary for cell growth, and oncogenes, the genes that produce cancer, are only two aspects. Proto-oncogenes are found in normal cellular DNA and are believed to play regulatory roles in differentiation and development. Oncoviruses, mutation of DNA and chromosomal damage ca...

ACCP Virtual Poster Symposium

1. Risk of lactobacillus infection in critically ill adults receiving lactobacillus probiotics. Zach Ruege, Pharm.D.; UGA College of Pharmacy, Augusta, GA INTRODUCTION: Probiotics have been advocated in critically ill patients to mitigate risk for developing Clostridium difficile infection and ventilator associated pneumonia. Critically ill patients display suppressed immune response of the int...

2010 Spring Symposium – Poster Presentations

Genetic markers for oncogenes, growth factors, and cystic fibrosis.

The techniques of molecular biology have had a dramatic effect on the advancement of human genetics. In particular, the development of restriction fragment length polymorphisms (RFLPs) has allowed researchers to generate genetic markers for virtually any region of the human genome. Most RFLPs occur when a mutation creates or deletes a recognition site for a restriction enzyme, generating a DNA ...

Hemopoietic growth factors and oncogenes in myeloid leukemia development.

Most primary myeloid leukemias are dependent for proliferative stimulation on the glycoprotein colony-stimulating factors. These agents are therefore mandatory co-factors in the development of myeloid leukemia. The CSFs also modify oncogene transcription, and in model leukemogenesis experiments GM-CSF has been shown to be a proto-oncogene. However, most evidence is against an autocrine hypothes...